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Article

Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis.

Nature cell biology - 1 Jun 2017

Celià-Terrassa Toni, Liu Daniel D, Choudhury Abrar, Hang Xiang, Wei Yong, Zamalloa Jose, Alfaro-Aco Raymundo, Chakrabarti Rumela, Jiang Yi-Zhou, Koh Bong Ihn, Smith Heath A, DeCoste Christina, Li Jun-Jing, Shao Zhi-Ming, Kang Yibin

Abstract excerpt

Tumour-initiating cells, or cancer stem cells (CSCs), possess stem-cell-like properties observed in normal adult tissue stem cells. Normal and cancerous stem cells may therefore share regulatory mechanisms for maintaining self-renewing capacity and resisting differentiation elicited by cell-intrinsic or microenvironmental cues. Here, we show that miR-199a promotes stem cell properties in mammary stem cells and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28530657
DOI: 10.1038/ncb3533
PMCID: PMC5481166

Genes

LCOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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