Article
Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study.
Human genetics - 1 Jul 2017
Lindström Sara, Germain Marine, Crous-Bou Marta, Smith Erin N, Morange Pierre-Emmanuel, van Hylckama Vlieg Astrid, de Haan Hugoline G, Chasman Daniel, Ridker Paul, Brody Jennifer, de Andrade Mariza, Heit John A, Tang Weihong, DeVivo Immaculata, Grodstein Francine, Smith Nicholas L, Tregouet David, Kabrhel Christopher
Abstract excerpt
Observational studies have shown an association between obesity and venous thromboembolism (VTE) but it is not known if observed associations are causal, due to reverse causation or confounding bias. We conducted a Mendelian Randomization study of body mass index (BMI) and VTE. We identified 95 single nucleotide polymorphisms (SNPs) that have been previously associated with BMI and assessed the association...
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