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Article

Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells.

Experimental cell research - 1 Aug 2017

Ahadome Sarah D, Zhang Chi, Tannous Elizabeth, Shen James, Zheng Jie J

Abstract excerpt

Trabecular meshwork (TM) cells are the governing regulators of the TM structure. When the functionality of these cells is impaired, the structure of the TM is perturbed which often results in increased ocular hypertension. High intraocular pressure is the most significant risk factor for steroid-induced glaucoma. Dexamethasone (Dex)-induced phenotype of TM cells is widely utilized as a model system to gain...

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Identifiers

PMID: 28526237
DOI: 10.1016/j.yexcr.2017.05.009
PMCID: PMC5535738

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