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Article

Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.

Biochemical pharmacology - 15 Aug 2017

Wang Ying, Zhou Chun, Gao Hui, Li Cuixian, Li Dong, Liu Peiqing, Huang Min, Shen Xiaoyan, Liu Liang

Abstract excerpt

BACKGROUND AND PURPOSE: The balance between T helper 17 (Th17) cells and regulatory T (Treg) cells, plays a critical role in rheumatoid arthritis (RA). The differentiation of Th17 cells requires the activation of STAT3, which determines the balance of Th17/Treg. Here, we investigated the therapeutic effect of Cryptotanshinone (CTS) on collagen induced mouse arthritis and explored the underlying mechanisms....

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Source

Identifiers

PMID: 28522406
DOI: 10.1016/j.bcp.2017.05.006

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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