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Article

Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC).

Oncotarget - 18 Jul 2017

Codony-Servat Carles, Codony-Servat Jordi, Karachaliou Niki, Molina Miguel Angel, Chaib Imane, Ramirez Jose Luis, de Los Llanos Gil Maria, Solca Flavio, Bivona Trever G, Rosell Rafael

Abstract excerpt

Gefitinib, erlotinib or afatinib are the current treatment for non-small-cell lung cancer (NSCLC) harboring an activating mutation of the epidermal growth factor receptor (EGFR), but less than 5% of patients achieve a complete response and the median progression-free survival is no longer than 12 months. Early adaptive resistance can occur as soon as two hours after starting treatment by activating signal...

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Source

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Identifiers

PMID: 28521301
DOI: 10.18632/oncotarget.17625
PMCID: PMC5564566

Genes

STAT3
EGFR
HES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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