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Genistein protects intervertebral discs from degeneration via Nrf2‐mediated antioxidant defense system: An in vitro and in vivo study

18 Feb 2019

Abstract excerpt

Oxidative stress has been reported to be closely associated with the development of intervertebral disc degeneration (IDD). IDD is one of the major causes of low back pain. Genistein (GES), one of the main isoflavones of soybean, has been shown to exert multiple biological functions on different diseases. Here, we tested the therapeutic potential of GES for IDD. In vitro experiments, we confirmed GES was nontoxic...

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PMID: 30779107
DOI: 10.1002/jcp.28301

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