"Conversion" of epistatic into additive genetic variance in finite populations and possible impact on long-term selection response.

Abstract excerpt

The role of epistasis in understanding the genetic architecture and variation of quantitative traits and its role, if any, in artificial selection and livestock improvement more generally has a long and sometimes controversial history. Its presence has been clearly demonstrated in, for example, laboratory experiments, but the amount of variation it contributes is likely to be small in outbred populations. In a...

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