Article
Mitochondrial DNA levels in Huntington disease leukocytes and dermal fibroblasts.
Metabolic brain disease - 1 Aug 2017
Jędrak Paulina, Krygier Magdalena, Tońska Katarzyna, Drozd Małgorzata, Kaliszewska Magdalena, Bartnik Ewa, Sołtan Witold, Sitek Emilia J, Stanisławska-Sachadyn Anna, Limon Janusz, Sławek Jarosław, Węgrzyn Grzegorz, Barańska Sylwia
Abstract excerpt
Huntington disease (HD) is an inherited neurodegenerative disorder caused by mutations in the huntingtin gene. Involvement of mitochondrial dysfunctions in, and especially influence of the level of mitochondrial DNA (mtDNA) on, development of this disease is unclear. Here, samples of blood from 84 HD patients and 79 controls, and dermal fibroblasts from 10 HD patients and 9 controls were analysed for mtDNA...
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