Characterization and role of a 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans.

doi:10.1007/s10529-017-2349-7

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Article

Characterization and role of a 2',3'-cyclic phosphodiesterase from Deinococcus radiodurans.

Biotechnology letters - 1 Aug 2017

Han Wanchun, Zhou Congli, Cheng Jiahui, Pan Mingzhe, Hua Yuejin, Zhao Ye

Abstract excerpt

OBJECTIVES: A 2',3'-cyclic phosphodiesterase gene (drCPDase) has been characterized from Deinococcus radiodurans and is involved in the robust resistance of this organism. RESULTS: Cells lacking 2',3'-cyclic phosphodiesterase gene (drCPDase) showed modest growth defects and displayed increased sensitivities to high doses of various DNA-damaging agents including ionizing radiation, mitomycin C, UV and H2O2. The...

Topics

Deinococcus
Escherichia coli
Hydrogen Peroxide
Microbial Viability
Mutation
Nucleotidases
Oxidative Stress
Recombinant Proteins

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PMID: 28497175
DOI: 10.1007/s10529-017-2349-7

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