Article
CIC break‐apart fluorescence in‐situ hybridization misses a subset of CIC – DUX 4 sarcomas: a clinicopathological and molecular study
11 May 2017
Abstract excerpt
AIMS: Approximately 60-70% of high-grade round-cell sarcomas that lack the Ewing sarcoma breakpoint region 1 (EWSR1) rearrangement harbour a rearrangement of the CIC gene, most commonly CIC-DUX4. Recent studies have established that CIC-rearranged sarcomas constitute a distinct group characterized by recognizable histology and immunoprofiles, such as positivity for ETV4 and WT1 and negativity for NKX2.2. Although...
Topics
Join the communities discussing this publication.