Article
A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.
The American journal of surgical pathology - 1 Nov 2014
Sugita Shintaro, Arai Yasuhito, Tonooka Akiko, Hama Natsuko, Totoki Yasushi, Fujii Tomoki, Aoyama Tomoyuki, Asanuma Hiroko, Tsukahara Tomohide, Kaya Mitsunori, Shibata Tatsuhiro, Hasegawa Tadashi
Abstract excerpt
Differential diagnosis of small round cell sarcomas (SRCSs) grouped under the Ewing sarcoma family of tumors (ESFT) can be a challenging situation for pathologists. Recent studies have revealed that some groups of Ewing-like sarcoma show typical ESFT morphology but lack any EWSR1-ETS gene fusions. Here we identified a novel gene fusion, CIC-FOXO4, in a case of Ewing-like sarcoma with a t(X;19)(q13;q13.3)...
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