Article
Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway.
Molecular medicine reports - 1 Jun 2017
Zhong Guangxin, Chen Lu, Yin Ruihong, Qu Yan, Bao Yongxing, Xiao Qiong, Zhang Zhaolin, Shen Yaqian, Li Cailing, Xu Yun, Zou Zhigeng, Tian Hua
Abstract excerpt
C-C chemokine receptor type 7 (CCR7) has been implicated in lymph node metastasis of various cancers. Previous studies have revealed that epithelial‑mesenchymal transition (EMT) is involved in the chemotactic process mediated by CCR7 and its ligands in various types of carcinoma. However, the underlying mechanism of this process remains to be fully elucidated. The present study investigated whether chemokine (C‑C...
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