Article
BAP1 mutations in high-grade meningioma: implications for patient care.
Neuro-oncology - 19 Oct 2017
Shankar Ganesh M, Santagata Sandro
Abstract excerpt
We have recently shown that the breast cancer (BRCA)1-associated protein-1 tumor suppressor gene (BAP1) is inactivated in a subset of clinically aggressive meningiomas that display rhabdoid histomorphology. Immunohistochemistry for BAP1 protein provides a rapid and inexpensive method for screening suspected cases. Notably, some patients with BAP1-mutant meningiomas have germline BAP1 mutations and BAP1 tumor...
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