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Article

Meningioma with trabecular architecture: a harbinger of BAP1 deficiency.

Brain tumor pathology - 1 Apr 2026

Okuno Noriko, Takahiro Tomita, Akai Takuya, Kuroda Satoshi, Takakura Hiromasa, Hirabayashi Kenichi, Sasahara Masakiyo, Kurose Akira, Takata Katsuyoshi

Abstract excerpt

BRCA (BReast CAncer gene)-associated protein 1 (BAP1) is a tumor suppressor protein encoded by the BAP1 gene. BAP1 mutations and the loss of BAP1 expression on immunohistochemistry are poor prognostic factors for meningiomas. These mutations have been previously reported in papillary and rhabdoid meningiomas. However, BAP1-deficient meningiomas with a trabecular architecture are rare, with only one previous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40944770
DOI: 10.1007/s10014-025-00516-0

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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