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Enhancing Lentiviral and Alpharetroviral Transduction of Human Hematopoietic Stem Cells for Clinical Application

7 Jun 2019

Abstract excerpt

Ex vivo retroviral gene transfer into CD34 + hematopoietic stem and progenitor cells (HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic hematopoietic disorders. However, little attention has been paid to enhancement of culture and transduction conditions to achieve reliable effects across patient and disease contexts and to maximize potential vector usage and reduce treatment cost....

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PMID: 31338385
DOI: 10.1016/j.omtm.2019.05.015

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