Article
Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases.
The American Journal of dermatopathology - 1 Feb 2018
Isales Maria C, Haugh Alexandra M, Bubley Jeffrey, Verzì Anna E, Zhang Bin, Kudalkar Emily, Lee Christina Y, Yazdan Pedram, Guitart Joan, Gerami Pedram
Abstract excerpt
Blitz nevi/tumors are a distinct subset of melanocytic neoplasia which show mixed morphologic features of Spitz and blue nevus. Genomically, most blue nevi have GNAQ or GNA11 mutations while most Spitzoid neoplasms have either an HRAS mutation or translocations involving MET, ROS, BRAF, ALK1, NTRK1, and RET. The criteria used for the assessment of malignancy in blue and Spitzoid lesions are different, and these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.