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Article

Functional significance of SPINK1 promoter variants in chronic pancreatitis.

American journal of physiology. Gastrointestinal and liver physiology - 1 May 2015

Derikx Monique H M, Geisz Andrea, Kereszturi Éva, Sahin-Tóth Miklós

Abstract excerpt

Chronic pancreatitis is a progressive inflammatory disorder of the pancreas, which often develops as a result of genetic predisposition. Some of the most frequently identified risk factors affect the serine protease inhibitor Kazal type 1 (SPINK1) gene, which encodes a trypsin inhibitor responsible for protecting the pancreas from premature trypsinogen activation. Recent genetic and functional studies indicated...

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Identifiers

PMID: 25792561
DOI: 10.1152/ajpgi.00022.2015
PMCID: PMC4421017

Genes

SPINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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