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Article

Toward a clinical diagnostic pipeline for SPINK1 intronic variants

12 Feb 2019

Abstract excerpt

BACKGROUND: The clinical significance of SPINK1 intronic variants in chronic pancreatitis has been previously assessed by various approaches including a cell culture-based full-length gene assay. A close correlation between the results of this assay and in silico splicing prediction was apparent. However, until now, a clinical diagnostic pipeline specifically designed to classify SPINK1 intronic variants...

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PMID: 30755276
DOI: 10.1186/s40246-019-0193-7

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