Article
HIV-1 strains belonging to large phylogenetic clusters show accelerated escape from integrase inhibitors in cell culture compared with viral isolates from singleton/small clusters.
The Journal of antimicrobial chemotherapy - 1 Aug 2017
Brenner Bluma G, Ibanescu Ruxandra-Ilinca, Oliveira Maureen, Roger Michel, Hardy Isabelle, Routy Jean-Pierre, Kyeyune Fred, Quiñones-Mateu Miguel E, Wainberg Mark A
Abstract excerpt
Objectives: Viral phylogenetics revealed two patterns of HIV-1 spread among MSM in Quebec. While most HIV-1 strains ( n = 2011) were associated with singleton/small clusters (cluster size 1-4), 30 viral lineages formed large networks (cluster size 20-140), contributing to 42% of diagnoses between 2011 and 2015. Herein, tissue culture selections ascertained if large cluster lineages possessed higher replicative...
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