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Article

Lineage-specific SNPs for genotyping of Mycobacterium tuberculosis clinical isolates.

Scientific reports - 3 May 2017

Dou Horng-Yunn, Lin Chien-Hsing, Chen Yih-Yuan, Yang Shiu-Ju, Chang Jia-Ru, Wu Keh-Ming, Chen Ying-Tsong, Chin Pei-Ju, Liu Yen-Ming, Su Ih-Jen, Tsai Shih-Feng

Abstract excerpt

Tuberculosis (TB) is a severe infectious disease worldwide. Genetic variation of the causative agent, Mycobacterium tuberculosis (MTB), determines the outcomes of infection and anti-TB treatment. Until recently, there has been no effective and convenient way for classifying clinical isolates based on the DNA sequences of the divergent lineages of MTB infecting human populations. Here, we identified single...

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PMID: 28469152
DOI: 10.1038/s41598-017-01580-z
PMCID: PMC5431204

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