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Article

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling.

Nature communications - 2 May 2017

Ishii Seiji, Torii Masaaki, Son Alexander I, Rajendraprasad Meenu, Morozov Yury M, Kawasawa Yuka Imamura, Salzberg Anna C, Fujimoto Mitsuaki, Brennand Kristen, Nakai Akira, Mezger Valerie, Gage Fred H, Rakic Pasko, Hashimoto-Torii Kazue

Abstract excerpt

Repetitive prenatal exposure to identical or similar doses of harmful agents results in highly variable and unpredictable negative effects on fetal brain development ranging in severity from high to little or none. However, the molecular and cellular basis of this variability is not well understood. This study reports that exposure of mouse and human embryonic brain tissues to equal doses of harmful chemicals,...

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Identifiers

PMID: 28462912
DOI: 10.1038/ncomms15157
PMCID: PMC5418582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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