Article
A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines.
Scientific reports - 28 Apr 2017
Wada Yamato, Nithichanon Arnone, Nobusawa Eri, Moise Leonard, Martin William D, Yamamoto Norio, Terahara Kazutaka, Hagiwara Haruhisa, Odagiri Takato, Tashiro Masato, Lertmemongkolchai Ganjana, Takeyama Haruko, De Groot Anne S, Ato Manabu, Takahashi Yoshimasa
Abstract excerpt
Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the human genome, the links between the T-cell epitopes and low immunogenicity of H7 HA remains unknown due to the lack of...
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