Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid.

doi:10.1007/s00277-017-3002-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid.

Annals of hematology - 1 Jul 2017

Sanchez Ricardo, Ayala Rosa, Alonso Rafael Alberto, Martínez María Pilar, Ribera Jordi, García Olga, Sanchez-Pina José, Mercadal Santiago, Montesinos Pau, Martino Rodrigo, Barba Pere, González-Campos José, Barrios Manuel, Lavilla Esperanza, Gil Cristina, Bernal Teresa, Escoda Lourdes, Abella Eugenia, Amigo Ma Luz, Moreno Ma José, Bravo Pilar, Guàrdia Ramón, Hernández-Rivas Jesús-María, García-Guiñón Antoni, Piernas Sonia, Ribera José-María, Martínez-López Joaquín

Abstract excerpt

We investigated the frequency, predictors, and evolution of acute lymphoblastic leukemia (ALL) in patients with CNS relapse and introduced a novel method for studying BCR-ABL1 protein variants in cDNA from bone marrow (BM) and cerebrospinal fluid (CSF) blast cells. A total of 128 patients were analyzed in two PETHEMA clinical trials. All achieved complete remission after imatinib treatment. Of these, 30 (23%)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feasibility Studies

Share to Fusion Proteins, bcr-abl

Share to Kaplan-Meier Estimate

Share to Outcome Assessment, Health Care

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-abl

Share to Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 28451802
DOI: 10.1007/s00277-017-3002-1
PMCID: PMC5486784

Genes

ABL1
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid.PMID 28451802Read ↗

Factors associated with risk of central nervous system relapse in patients with non-core binding factor acute myeloid leukemia.Semantic proximity Read ↗

Isolated central nervous system relapse in patient with blast-crisis chronic myeloid leukemia in durable complete cytogenetic remission on dasatinib treatment: pharmacokinetics and ABL mutation analysis in cerebrospinal fluid.Semantic proximity Read ↗

Isolated central nervous system relapse in two patients with BCR-ABL-positive acute leukemia while receiving a next-generation tyrosine kinase inhibitor.Semantic proximity Read ↗

Flow cytometric detection of isolated central nervous system relapse in acute myeloid leukemia under FLT3-targeted therapy.Semantic proximity Read ↗

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.Semantic proximity Read ↗

Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche.Semantic proximity Read ↗

Subclonal NT5C2 mutations are associated with poor outcomes after relapse of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

An abnormality in the cerebrospinal fluid before transplantation is predictive of poor outcomes after allotransplantation in AML patientsSemantic proximity Read ↗

Clonal evolution in diffuse large B-cell lymphoma with central nervous system recurrenceSemantic proximity Read ↗

CNS relapse in acute promyeloctyic leukemia.Semantic proximity Read ↗

Clonal Evolution in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System.Semantic proximity Read ↗

The evolution of relapse of adult T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.