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Article

The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity.

Biomedical research (Tokyo, Japan) - 1 Jan 2017

Tsuda Yoshimi, Igarashi Manabu, Ito Ryo, Nishio Sanae, Shimizu Kenta, Yoshimatsu Kumiko, Arikawa Jiro

Abstract excerpt

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus responsible for causing an emerging zoonotic disease. We previously established subclones from SFTSV strain YG1 based on differences in low-pH-dependent cell fusion activities and found two amino acid substitutions, Y328H and R624W, in the envelope glycoprotein (GP) of high fusion subclones. In this study, we show that transiently...

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PMID: 28442665
DOI: 10.2220/biomedres.38.89

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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