Article

Characterization of severe fever with thrombocytopenia syndrome virus Japanese isolate YG1 strain quasispecies using reverse genetics approaches

2024-02-02

Abstract excerpt

Three amino acid mutations have been identified in the isolated YG1 strain of severe fever thrombocytopenia syndrome virus (SFTSV), Gn (Y328H) accounts for 26.9% of the virus in patients’ blood, Gc (R624W) and L (N1891K) those are minor. To investigate viral properties caused by each mutation, we rescued viruses with one–three mutations. Mutations Y328H and R624W in GP increased the cell fusion activity and plaque...

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Literature Corpus work: d5fb9931-cd37-5016-ba52-a9dbc9ceec73
DOI: 10.1101/2024.02.01.578508

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