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Article

Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer

26 Apr 2017

Abstract excerpt

Abstract Wee1 is a protein kinase that regulates the G2 checkpoint and prevents entry into mitosis in response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 serine/threonine protein kinases that coordinate the progression through the cell cycle. The Cdc2/cyclin B complex controls the progression from G2 into mitosis. There are two mechanisms by which the G2 checkpoint is initiated in response...

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PMID: 28442503
DOI: 10.1158/1078-0432.ccr-17-0520

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