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Article

An integrated chemical biology approach reveals the mechanism of action of HIV replication inhibitors.

Bioorganic & medicinal chemistry - 1 Dec 2017

Pagano Nicholas, Teriete Peter, Mattmann Margrith E, Yang Li, Snyder Beth A, Cai Zhaohui, Heil Marintha L, Cosford Nicholas D P

Abstract excerpt

Continuous flow (microfluidic) chemistry was employed to prepare a small focused library of dihydropyrimidinone (DHPM) derivatives. Compounds in this class have been reported to exhibit activity against the human immunodeficiency virus (HIV), but their molecular target had not been identified. We tested the initial set of DHPMs in phenotypic assays providing a hit (1i) that inhibited the replication of the human...

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Identifiers

PMID: 28442262
DOI: 10.1016/j.bmc.2017.03.061
PMCID: PMC6145176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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