Diversified cell origin of Helicobacter pylori eradication-responsive gastric diffuse large B-cell lymphomas.

doi:10.1002/path.70091

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Article

Diversified cell origin of Helicobacter pylori eradication-responsive gastric diffuse large B-cell lymphomas.

The Journal of pathology - 1 Oct 2026

Kuo Sung-Hsin, Yeh Kun-Huei, Lin Chung-Wu, Chen Li-Tzong, Liou Jyh-Ming, Shun Chia-Tung, Lee Hsiao-Wei, Wei Ming-Feng, Wang Hsiu-Po, Wu Ming-Shiang, Cheng Ann-Lii

Abstract excerpt

A significant proportion of gastric diffuse large B-cell lymphoma with mucosa-associated lymphoid tissue [DLBCL(MALT)] and without MALT ('pure' DLBCL) can be resolved by Helicobacter pylori eradication (HPE). Gastric MALT lymphoma is an indolent lymphoma derived from memory B cells in the marginal zone. In the present study, we aimed to explore the origin of large cells in HPE-responsive gastric DLBCLs (complete...

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Topics

Humans
Lymphoma, Large B-Cell, Diffuse
Stomach Neoplasms
Helicobacter pylori
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Helicobacter Infections

Aged

Germinal Center

Adult

Lymphoma, B-Cell, Marginal Zone

Biomarkers, Tumor

Mutation

Gene Expression Profiling

Enhancer of Zeste Homolog 2 Protein

Aged, 80 and over

Anti-Bacterial Agents

Source

Open in PubMed Open full text

Identifiers

PMID: 42554009
DOI: 10.1002/path.70091
PMCID: PMC13576759

Genes

BACH2
BCL2

Provenance

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