Article
Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.
Drug design, development and therapy - 1 Jan 2017
da Silva Cristiane França, Batista Denise da Gama Jaén, de Araújo Julianna Siciliano, Cunha-Junior Edézio Ferreira, Stephens Chad E, Banerjee Moloy, Farahat Abdelbasset A, Akay Senol, Fisher Mary K, Boykin David W, Soeiro Maria de Nazaré Correia
Abstract excerpt
Arylimidamides (AIAs), previously termed as reversed amidines, present a broad spectrum of activity against intracellular microorganisms. In the present study, three novel AIAs were evaluated in a mouse model of Trypanosoma cruzi infection, which is the causative agent of Chagas disease. The bis-AIAs DB1957, DB1959 and DB1890 were chosen based on a previous screening of their scaffolds that revealed a very...
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