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Article

Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi.

Antimicrobial agents and chemotherapy - 1 Aug 2016

Simões-Silva M R, Nefertiti A S G, De Araújo J S, Batista M M, Da Silva P B, Bahia M T, Menna-Barreto R S, Pavão B P, Green J, Farahat A A, Kumar A, Boykin D W, Soeiro M N C

Abstract excerpt

The current treatment of Chagas disease (CD), based on nifurtimox and benznidazole (Bz), is unsatisfactory. In this context, we performed the phenotypic in vitro screening of novel mono- and diamidines and drug interaction assays with selected compounds. Ten novel amidines were tested for their activities against bloodstream trypomastigote (BT) and amastigote forms of Trypanosoma cruzi (Y and Tulahuen strains)...

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Identifiers

PMID: 27216059
DOI: 10.1128/AAC.01788-15
PMCID: PMC4958229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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