Article
Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma.
Biochemical and biophysical research communications - 3 Jun 2017
Yamaguchi Miki, Hirai Sachie, Sumi Toshiyuki, Tanaka Yusuke, Tada Makoto, Nishii Yukari, Hasegawa Tadashi, Uchida Hiroaki, Yamada Gen, Watanabe Atsushi, Takahashi Hiroki, Sakuma Yuji
Abstract excerpt
EGFR-mutant lung adenocarcinomas contain a subpopulation of cells that have undergone epithelial-to-mesenchymal transition and can grow independently of EGFR. To kill these cancer cells, we need a novel therapeutic approach other than EGFR inhibitors. If a molecule is specifically expressed on the cell surface of such EGFR-independent EGFR-mutant cancer cells, it can be a therapeutic target. We found that a...
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