Article
Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease.
Investigacion clinica - 1 Jun 2016
Martínez Daniela, Lema Diego, Del Carmen Moreno Dolores, Hipólito García Alexis, Valentina Garmendia Jenny, De Sanctis Juan Bautista
Abstract excerpt
ADAM33 is a metalloproteinase important in the extracellular matrix for tissue remodeling, and, consequently, in asthma and chronic obstructive pulmonary disease (COPD). Several polymorphisms of the ADAM33 gene have been associated with enzyme activity. One of the most studied polymorphisms is V4, cytosine for guanine in the 3 'UTR region, and T1, adenine for guanine in the exon 19 of the gen. The aim of this...
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