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Article

Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei.

PloS one - 1 Jan 2017

Saarinen Lilli, Nummela Pirjo, Thiel Alexandra, Lehtonen Rainer, Järvinen Petrus, Järvinen Heikki, Aaltonen Lauri A, Lepistö Anna, Hautaniemi Sampsa, Ristimäki Ari

Abstract excerpt

Pseudomyxoma peritonei (PMP) is a subtype of mucinous adenocarcinoma mainly restricted to the peritoneal cavity and most commonly originating from the appendix. The genetic background of PMP is poorly understood and no targeted treatments are currently available for this fatal disease. While RAS signaling pathway is affected in most if not all PMP cases and over half of them also have a mutation in the GNAS gene,...

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Identifiers

PMID: 28426742
DOI: 10.1371/journal.pone.0174898
PMCID: PMC5398530

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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