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Article

A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma.

Oncotarget - 23 May 2017

Lin Chiao-Wen, Chou Ying-Erh, Yeh Chia-Ming, Yang Shun-Fa, Chuang Chun-Yi, Liu Yu-Fan

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is a common malignancy that has been causally associated with both hereditary and acquired factors. The high mobility group box 1 (HMGB1) gene plays an important role as a DNA chaperone to help maintain nuclear homeostasis. Altered expression of HMGB1 has been implicated in a wide range of pathological processes, including inflammation and cancer. The present study explores the...

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Identifiers

PMID: 28423715
DOI: 10.18632/oncotarget.16120
PMCID: PMC5470997

Genes

HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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