Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1

17 Apr 2017

Abstract excerpt

The oncogenic transcription factor FoxM1 plays a vital role in cell cycle progression, is activated in numerous human malignancies, and is linked to chromosome instability. We characterize here a cullin 4-based E3 ubiquitin ligase and its substrate receptor, VprBP/DCAF1 (CRL4VprBP), which we show regulate FoxM1 ubiquitylation and degradation. Paradoxically, we also found that the substrate receptor VprBP is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to FOXO transcription factor regulation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28416635
DOI: 10.1128/mcb.00609-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

VprBP/DCAF1 Regulates the Degradation and Nonproteolytic Activation of the Cell Cycle Transcription Factor FoxM1PMID 28416635Read ↗

DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptorSemantic proximity Read ↗

PIN1 and CDK1 cooperatively govern pVHL stability and suppressive functionsSemantic proximity Read ↗

Cullin-RING Ligase 5: Functional characterization and its role in human cancersSemantic proximity Read ↗

Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatinSemantic proximity Read ↗

DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting <i>PERP</i> expressionSemantic proximity Read ↗

The awakening of the CDK10/Cyclin M protein kinaseSemantic proximity Read ↗

CRL4BDCAF11 E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cellsSemantic proximity Read ↗

Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycleSemantic proximity Read ↗

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.Semantic proximity Read ↗

VCP/p97 targets the nuclear export and degradation of p27 Kip1 during G1 to S phase transitionSemantic proximity Read ↗

Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitorsSemantic proximity Read ↗

TRAP1 controls cell cycle G2–M transition through the regulation of CDK1 and MAD2 expression/ubiquitinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.