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Article

Increased B cell activation is present in JAK2V617F-mutated, CALR-mutated and triple-negative essential thrombocythemia.

Oncotarget - 16 May 2017

Lim Ken-Hong, Chen Caleb Gon-Shen, Chang Yu-Cheng, Chiang Yi-Hao, Kao Chen-Wei, Wang Wei-Ting, Chang Chiao-Yi, Huang Ling, Lin Ching-Sung, Cheng Chun-Chia, Cheng Hung-I, Su Nai-Wen, Lin Johnson, Chang Yi-Fang, Chang Ming-Chih, Hsieh Ruey-Kuen, Lin Huan-Chau, Kuo Yuan-Yeh

Abstract excerpt

Essential thrombocythemia (ET) is a BCL-ABL1-negative myeloproliferative neoplasm. We have reported that increased activated B cells can facilitate platelet production mediated by cytokines regardless JAK2 mutational status in ET. Recently, calreticulin (CALR) mutations were discovered in ~30% JAK2/MPL-unmutated ET and primary myelofibrosis. Here we sought to screen for CALR mutations and to evaluate B cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28415571
DOI: 10.18632/oncotarget.16381
PMCID: PMC5464803

Genes

CALR
JAK2
TLR4
ABL1
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased B cell activation is present in JAK2V617F-mutated, CALR-mutated and triple-negative essential thrombocythemia.PMID 28415571Read ↗

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From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms.Semantic proximity Read ↗

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