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Article

Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

24 Nov 2015

Abstract excerpt

Development of uterine endometrial receptivity for implantation is orchestrated by cyclic steroid hormone-mediated signals. It is unknown if these signals are necessary for oviduct function in supporting fertilization and preimplantation development. Here we show that conditional knockout (cKO) mice lacking estrogen receptor α (ERα) in oviduct and uterine epithelial cells have impaired fertilization due to a...

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PMID: 26623518
DOI: 10.7554/elife.10453

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