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Fetal testis organ culture reproduces the dynamics of epigenetic reprogramming in rat gonocytes

11 Apr 2017

Abstract excerpt

Epigenetic reprogramming is a critical step in male germ cell development that occurs during perinatal life. It is characterized by the remodeling of different epigenetic marks such as DNA methylation (5mC) and methylation of histone H3. It has been suggested that endocrine disruptors can affect the male germline epigenome by altering epigenetic reprogramming, but the mechanisms involved are still unknown. We...

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PMID: 28413450
DOI: 10.1186/s13072-017-0127-3

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