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Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis

15 Apr 2017

Abstract excerpt

OBJECTIVE: Accumulating evidence supports a role for exosomes in immune regulation. In this study, we investigated the total circulating exosome transcriptome in relapsing-remitting multiple sclerosis (RRMS) patients and healthy controls (HC). METHODS: Next generation sequencing (NGS) was used to define the global RNA profile of serum exosomes in 19 RRMS patients (9 in relapse, 10 in remission) and 10 HC. We...

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PMID: 28411393
DOI: 10.1002/ana.24931

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