Article

Addiction as a Chronic Brain Disease: A Narrative Review of the Neurobiological Evidence

2026-08-06

Abstract excerpt

<p>Addiction has traditionally been explained in moral terms, as a failure of discipline repeated onetoo many times. Three decades of neuroscience research complicate that story considerably.Repeated exposure to alcohol and other drugs changes how the brain's reward circuitry respondsto everyday experience, weakens the prefrontal systems responsible for planning and impulsecontrol, and leaves behind changes to str...

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Literature Corpus work: 713d7b71-178e-52d9-896b-0e910bfabe55
DOI: 10.31234/osf.io/m8g6k_v1

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