Nucleic acid detection with CRISPR-Cas13a/C2c2.

doi:10.1126/science.aam9321

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Article

Nucleic acid detection with CRISPR-Cas13a/C2c2.

Science (New York, N.Y.) - 28 Apr 2017

Gootenberg Jonathan S, Abudayyeh Omar O, Lee Jeong Wook, Essletzbichler Patrick, Dy Aaron J, Joung Julia, Verdine Vanessa, Donghia Nina, Daringer Nichole M, Freije Catherine A, Myhrvold Cameron, Bhattacharyya Roby P, Livny Jonathan, Regev Aviv, Koonin Eugene V, Hung Deborah T, Sabeti Pardis C, Collins James J, Zhang Feng

Abstract excerpt

Rapid, inexpensive, and sensitive nucleic acid detection may aid point-of-care pathogen detection, genotyping, and disease monitoring. The RNA-guided, RNA-targeting clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas13a (previously known as C2c2) exhibits a "collateral...

Topics

Bacteria
Bacterial Proteins
Circulating Tumor DNA
Clustered Regularly Interspaced Short Palindromic Repeats
DNA, Bacterial
Dengue
Dengue Virus
Humans
Mutation
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point-of-Care Systems

RNA Cleavage

RNA, Viral

Ribonucleases

Zika Virus

Zika Virus Infection

Source

Open in PubMed Open full text

Identifiers

PMID: 28408723
DOI: 10.1126/science.aam9321
PMCID: PMC5526198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-28408723-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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