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Article

C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy.

PloS one - 1 Jan 2017

Panayiotou Elena, Fella Eleni, Papacharalambous Revekka, Malas Stavros, Saraiva Maria Joao, Kyriakides Theodoros

Abstract excerpt

ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation co-localizes with amyloid deposits in amyloidotic neuropathy and is possibly involved in the kinetics of...

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Identifiers

PMID: 28407005
DOI: 10.1371/journal.pone.0175767
PMCID: PMC5391113

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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