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Article

Molecular pathways associated with blood pressure and hexadecanedioate levels.

PloS one - 1 Jan 2017

Menni Cristina, Metrustry Sarah J, Ehret Georg, Dominiczak Anna F, Chowienczyk Phil, Spector Tim D, Padmanabhan Sandosh, Valdes Ana M

Abstract excerpt

The dicarboxylic acid hexadecanedioate is associated with increased blood pressure (BP) and mortality in humans and feeding it to rats raises BP. Here we aim to characterise the molecular pathways that influence levels of hexadecanedioate linked to BP regulation, using genetic and transcriptomic studies. The top associations for hexadecanedioate in a genome-wide association scan (GWAS) conducted on 6447...

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Identifiers

PMID: 28403188
DOI: 10.1371/journal.pone.0175479
PMCID: PMC5389832

Genes

DBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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