Article
Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study.
The journals of gerontology. Series A, Biological sciences and medical sciences - 2 Mar 2018
Yamada Yosuke, Kemnitz Joseph W, Weindruch Richard, Anderson Rozalyn M, Schoeller Dale A, Colman Ricki J
Abstract excerpt
Calorie restriction without malnutrition increases longevity and delays the onset of age-associated disorders in multiple species. Recently, greater emphasis has been placed on healthy life span and preventing frailty than on longevity. Here, we show the beneficial effect of long-term calorie restriction on frailty in later life in a nonhuman primate. Frail phenotypes were evaluated using metabolic and physical...
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