Article
Volumetric brain changes in females with fragile X-associated tremor/ataxia syndrome (FXTAS).
Neurology - 28 Aug 2007
Adams J S, Adams P E, Nguyen D, Brunberg J A, Tassone F, Zhang W, Koldewyn K, Rivera S M, Grigsby J, Zhang L, DeCarli C, Hagerman P J, Hagerman R J
Abstract excerpt
BACKGROUND: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder occurring in male and rare female carriers of a premutation expansion (55 to 200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene. METHODS: Volumetric MRI studies, clinical staging, cognitive testing, and molecular analysis were conducted in 15 female premutation carriers affected by FXTAS (age...
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