Identification of residues critical for proton-coupled glutathione translocation in the yeast glutathione transporter, Hgt1p.

Abstract excerpt

The proton gradient acts as the driving force for the transport of many metabolites across fungal and plant plasma membranes. Identifying the mechanism of proton relay is critical for understanding the mechanism of transport mediated by these transporters. We investigated two strategies for identifying residues critical for proton-dependent substrate transport in the yeast glutathione transporter, Hgt1p, a member...

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