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Article

Amino acid screening based on structural modeling identifies critical residues for the function, ion selectivity and structure of Arabidopsis MTP1.

The FEBS journal - 1 Jul 2012

Kawachi Miki, Kobae Yoshihiro, Kogawa Sayaka, Mimura Tetsuro, Krämer Ute, Maeshima Masayoshi

Abstract excerpt

Arabidopsis thaliana MTP1 is a vacuolar membrane Zn(2+)/H(+) antiporter of the cation diffusion facilitator family. Here we present a structure-function analysis of AtMTP1-mediated transport and its remarkable Zn(2+) selectivity by functional complementation tests of more than 50 mutant variants in metal-sensitive yeast strains. This was combined with homology modeling of AtMTP1 based on the crystal structure of...

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Identifiers

PMID: 22520078
DOI: 10.1111/j.1742-4658.2012.08613.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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