Article
Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.
Cell stem cell - 6 Apr 2017
Pashos Evanthia E, Park YoSon, Wang Xiao, Raghavan Avanthi, Yang Wenli, Abbey Deepti, Peters Derek T, Arbelaez Juan, Hernandez Mayda, Kuperwasser Nicolas, Li Wenjun, Lian Zhaorui, Liu Ying, Lv Wenjian, Lytle-Gabbin Stacey L, Marchadier Dawn H, Rogov Peter, Shi Jianting, Slovik Katherine J, Stylianou Ioannis M, Wang Li, Yan Ruilan, Zhang Xiaolan, Kathiresan Sekar, Duncan Stephen A, Mikkelsen Tarjei S, Morrisey Edward E, Rader Daniel J, Brown Christopher D, Musunuru Kiran
Abstract excerpt
Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to generate induced pluripotent stem cells (iPSCs) and hepatocyte-like cells (HLCs) for genome-wide mapping of expression quantitative trait loci (eQTLs) and allele-specific expression (ASE). We identified...
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