Article
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival.
International journal of cancer - 1 Jul 2017
Helland Å, Brustugun O T, Nakken S, Halvorsen A R, Dønnem T, Bremnes R, Busund L T, Sun J, Lorenz S, Solberg S K, Jørgensen L H, Vodak D, Myklebost O, Hovig E, Meza-Zepeda L A
Abstract excerpt
Lung cancer is the leading cause of cancer related death, and the past years' improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several new therapies that target protein kinases have been implemented, and many more are becoming available. We have investigated lung cancer specimens for somatic mutations in a targeted panel of 612...
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