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Article

Human skeletal muscle fibroblasts stimulate in vitro myogenesis and in vivo muscle regeneration

30 Mar 2017

Abstract excerpt

KEY POINTS: Accumulation of skeletal muscle extracellular matrix is an unfavourable characteristic of many muscle diseases, muscle injury and sarcopenia. The extent of cross-talk between fibroblasts, as the source of matrix protein, and satellite cells in humans is unknown. We studied this in human muscle biopsies and cell-culture studies. We observed a strong stimulation of myogenesis by human fibroblasts in...

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PMID: 28369879
DOI: 10.1113/jp273997

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